Even After Losing Weight with Mounjaro, the Rebound… What Is the Price of the “Perfect Body” Promised by Next-Generation Obesity Drugs?
【Genre】Science, Ethics
日本語(original) | English version | 繁體中文（台灣）版 | Tiếng Việt
Hello everyone. This is Akira.
“Mounjaro” is something you see a lot on social media these days.
Originally developed as a diabetes treatment, it has gained massive attention for weight loss, with many people claiming “I lost over 10kg in six months.”
At the same time, news of illegal resales and health problems is also increasing.
The Wall of Current Drugs Represented by Mounjaro: Rebound and the Cost of “Having to Take It for Life”
Mounjaro strongly suppresses appetite and delivers excellent weight loss results.
However, it has a major problem: it is very easy to rebound once you stop taking it.
The same is true for classical drugs like Mazindol and current GLP-1 drugs.
Clinical data shows that 50–70% of the lost weight often returns within one year after discontinuation.
In other words, with current drugs, there is a real cost: “If you stop, you’ll gain weight again, so you have to keep taking it for the rest of your life.”
Your body becomes dependent on the drug, you lose the power to manage yourself, and you live with the constant feeling that “I’m relying on medicine.”
The World of “Zero Rebound” Promised by Next-Generation Obesity Drugs and a New Cost
Next-generation drugs (such as GYM329) that aim to overcome this rebound problem seek to maintain muscle mass and basal metabolism to create a body that is “hard to gain weight even after stopping the drug.”
“Finally, I can get the perfect body and stop taking the medicine.”
Such expectations are emerging.
However, there is another cost here.
If we can obtain a “perfect body” with almost no effort and eliminate the worry of rebound, what will we lose?
Nietzsche’s “Übermensch” was a being who overcame themselves through pain and effort.
In contrast, what next-generation drugs offer is passive “optimization” that requires almost no effort.
This may give us superficial rest, but it quietly steals the true blank space of the heart — the time to face ourselves deeply and live in non-action.
The “easy rest” provided by drugs is not true inner fulfillment, but a false freedom created by dependency.
Modern disciplinary society constantly demands results, but the drugs whisper “You don’t have to try so hard,” while gradually eroding the sense that you are in control of your own life.
In the End, What Do We Choose?
Current drugs come with the real chain of “having to take them for life,” while next-generation drugs come with the cost of “losing the true blank space of the heart due to giving up effort.”
Drugs are certainly convenient tools.
However, a way of living that cherishes the blank space of the heart at your own pace, without relying on drugs, may be the path that quietly exerts power amid the suffocating pressures of modern society.
Naturally accepting time to “do nothing” and affirming yourself in power-saving mode — such a gentle way of being may be the wisdom left to us.
What do you think?
Akira
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